Hsv vaccine study

This may be the most promising herpes vaccine ever ...

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And while the recent study focused on prevention, it's possible the vaccine will also help mitigate symptoms and lower transmission risk in people already suffering from HSV-2. Friedman is hopeful ...

This may be the most promising herpes vaccine ever ...

Herpes simplex research - Wikipedia

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A therapeutic bivalent vaccine candidate for genital herpes simplex virus type 2 (HSV-2) did not meet its primary clinical study endpoint of annualized lesion recurrence rate. This rate is calculated based on those genital recurrences that were both clinically- and virologically-confirmed during a minimum of nine months of surveillance.

Herpes simplex research - Wikipedia

Herpes Vaccine Candidate Fails in Phase 2 Study ...

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8/2/2013 · Herpes simplex virus 2 (HSV-2) causes genital herpes and increases the risk of acquisition and transmission of HIV. An HSV-2 vaccine is not available. We will study a replication-defective HSV-2 vaccine, HSV529, that is deleted for 2 essential viral proteins, that can infect, but not replicate in …

Herpes Vaccine Candidate Fails in Phase 2 Study ...

Study of the Safety of a Particular Herpes Vaccine in ...

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8/17/2012 · Safety and Immunogenicity Study of Therapeutic HSV-2 Vaccine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Study of the Safety of a Particular Herpes Vaccine in ...

Safety and Immunogenicity Study of Therapeutic HSV-2 ...

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2. HSV-2 Pathogenesis. Though a great advance has been made in the study of HSV-2 pathology recently, little is known about the pathogenesis, which needs to be further examined [].HSV-2 entry requires the combination of viral glycoprotein D (gD) with its receptors, including herpesvirus entry mediator (HVEM), nectin-1 and -2, and specific sites in heparan sulfate [].

Safety and Immunogenicity Study of Therapeutic HSV-2 ...

HSV-2 Vaccine: Current Status and Insight into Factors for ...

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Vical is developing the HSV-2 therapeutic vaccine, VCL-HB01, to treat patients with symptomatic genital herpes infection. This vaccine candidate is currently being evaluated in a Phase 2 study in healthy adult subjects, 18 to 50 years of age who are randomized 2:1 to receive either vaccine or …

HSV-2 Vaccine: Current Status and Insight into Factors for ...

Is There An HSV-2 Vaccine Available? — Precision Vaccinations

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12/14/2013 · The study is expected to be completed by October 2016. Read more here. An effective HSV-2 vaccine would be great news from a public health point of view, and for those who are most at risk of getting infected (those who are most sexually active, with multiple partners).

Is There An HSV-2 Vaccine Available? — Precision Vaccinations

HSV-2 Vaccine – Is It Close? | Herpes Cure Breakthrough

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NIH launches trial of investigational genital herpes vaccine. ... Lesia K. Dropulic, M.D., of NIAID’s Laboratory of Infectious Diseases, the trial will test an investigational HSV-2 vaccine candidate, called HSV529, for safety and the ability to generate an immune system response. ... The study is expected to be completed by October 2016.

HSV-2 Vaccine – Is It Close? | Herpes Cure Breakthrough

NIH launches trial of investigational genital herpes ...

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Two previous studies of a herpes simplex virus type 2 (HSV-2) subunit vaccine containing glycoprotein D in HSV-discordant couples revealed 73% and 74% efficacy against genital disease in women who ...

NIH launches trial of investigational genital herpes ...

Efficacy Results of a Trial of a Herpes Simplex Vaccine | NEJM

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The University of Washington is seeking volunteers for a Phase 1 genital herpes (HSV-2) vaccine study. The purpose of this study is to test whether HSV529, an experimental herpes vaccine, increases the amount and type of immune system cells that come to your skin when you have a …

Efficacy Results of a Trial of a Herpes Simplex Vaccine | NEJM

Genital Herpes (HSV-2) Vaccine Study (Sanofi HSV529)

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12/1/2011 · Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 …

Genital Herpes (HSV-2) Vaccine Study (Sanofi HSV529)

HSV-2: in pursuit of a vaccine - PubMed Central (PMC)

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Herpes Simplex Virus (HSV) Vaccine Development Update Sami Gottlieb, MD, MSPH World Health Organization Carolyn Deal, PhD U.S. National Institutes of Health, ... study of replication-defective HSV-2 dl5-29 Healthy adult subjects 18-40 years of age with or without HSV infection

HSV-2: in pursuit of a vaccine - PubMed Central (PMC)

Herpes Simplex Virus (HSV) Vaccine Development Update

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Herpes simplex is a viral infection caused by the herpes simplex virus. Infections are categorized based on the part of the body infected. Oral herpes involves the face or mouth. It may result in small blisters in groups often called cold sores or fever blisters or may just cause a sore throat. Genital herpes, often simply known as herpes, may have minimal symptoms or form blisters that break ...

Herpes Simplex Virus (HSV) Vaccine Development Update

Herpes simplex - Wikipedia

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11/1/2008 · We conducted a double-blind, vehicle-controlled, dose escalation safety and immunogenicity trial of a candidate herpes simplex virus type 2 (HSV-2) surface glycoprotein D2 (gD2) DNA vaccine administered by use of a needle-free device. Sixty-two healthy adults were randomized using a 4:1 vaccine-to-placebo ratio. Half of the participants were HSV-1 seronegative, and all were HSV-2 …

Herpes simplex - Wikipedia

Phase I Study of a Herpes Simplex Virus Type 2 (HSV-2) DNA ...

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Herpes simplex virus (HSV) infections are endemic throughout the world. 1-3 In both point-prevalence and prospective studies, a large percentage of persons who are seropositive for HSV type 1 (HSV ...

Phase I Study of a Herpes Simplex Virus Type 2 (HSV-2) DNA ...

A Prospective Study of New Infections with Herpes Simplex ...

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3/10/2015 · It was generally assumed that an effective HSV-2 vaccine must stimulate the body to produce neutralizing antibodies—particularly against a viral surface protein called glycoprotein D (gD-2) that HSV-2 uses to enter human cells. A protein that triggers antibody production is called an antigen.

A Prospective Study of New Infections with Herpes Simplex ...

Experimental Herpes Vaccine Upends Traditional Approach ...

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HERPES: Vaccines for HSV. Author links open overlay panel Lawrence R. Stanberry MD, PhD * Show more. ... the dose of vaccine used in the Merck study was later determined to be minimally immunogenic, thereby raising the question of whether the vaccine would have worked if a higher dose had been used. Regrettably, this question was not answered ...

Experimental Herpes Vaccine Upends Traditional Approach ...

HERPES: Vaccines for HSV - ScienceDirect

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1/19/2017 · Perelman School of Medicine at the University of Pennsylvania. (2017, January 19). New genital herpes vaccine candidate provides powerful protection in preclinical tests. ScienceDaily…

HERPES: Vaccines for HSV - ScienceDirect

New genital herpes vaccine candidate provides powerful ...

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6/19/2013 · New study shows HPV vaccine helping lower HPV infection rates in teen girls. A new study looking at the prevalence of human papillomavirus (HPV) infections in girls and women before and after the introduction of the HPV vaccine shows a significant reduction in vaccine-type HPV in U.S. teens.

New genital herpes vaccine candidate provides powerful ...

New study shows HPV vaccine helping lower HPV infection ...

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4/15/2019 · Oct. 20, 2017 — A new study offers a rare glimpse into the genetics of a herpes simplex virus transmission event -- information that may prove useful in future development of therapeutics and ...

New study shows HPV vaccine helping lower HPV infection ...

Herpes News -- ScienceDaily

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1/30/2017 · Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted pathogen that often causes recurrent genital lesions. Transmission occurs largely from asymptomatic genital tract virus shedding, making this a key target for a therapeutic HSV vaccine.

Herpes News -- ScienceDaily
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