Genehunter linkage analysis study

GeneHunter - omicX

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Allows the very rapid extraction of complete multipoint inheritance information from pedigrees of moderate size. This information is then used in exact computation of multipoint LOD scores and in a powerful method of non-parametric linkage analysis. Quick calculations involving dozens of markers, even in pedigrees with inbreeding and marriage loops, is possible with GENEHUNTER.

GeneHunter - omicX

Genetic linkage analysis in the age ... - PubMed Central (PMC)

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Linkage analysis was the predominant statistical genetic mapping approach used in the latter half of the twentieth century. More recently, the focus shifted to association studies of complex traits that analyse common variants, which have a modest effect.

Genetic linkage analysis in the age ... - PubMed Central (PMC)

Genetic Linkage Analysis - an overview | ScienceDirect Topics

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Genetic Linkage Analysis. Genetic linkage analysis is a mainstay of disease gene identification, and additional methods such as SNP-based genetic maps and whole-exome sequencing approaches have enhanced robustness of the zebrafish model (Bradley et al., 2007; Guryev et al., 2006).

Genetic Linkage Analysis - an overview | ScienceDirect Topics

Comparison of GENEHUNTER and MFLINK for analysis of COGA ...

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Comparison of GENEHUNTER and MFLINK for analysis of COGA linkage data ... model-free methods of linkage analysis, the GENEHUNTER [Kruglyak and Lander, …

Comparison of GENEHUNTER and MFLINK for analysis of COGA ...

Genetic linkage studies - ScienceDirect

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9/23/2005 · Results of genetic linkage studies are often reported in the form of LOD scores. These scores are actually based on likelihood ratios. The use of maximum likelihood in genetic linkage analysis was originally proposed in 1947. 4 Its use became widespread once Morton 5 published his log-odd (LOD) tables, which enabled the sequential analysis of family-based linkage studies.

Genetic linkage studies - ScienceDirect

Genetic linkage analysis bioinformatics tools | GWAS - omicX

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For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis ...

Genetic linkage analysis bioinformatics tools | GWAS - omicX

Genomewide Linkage Analysis of Body Mass Index across 28 ...

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We performed a genomewide linkage analysis of six separate measurements of body mass index (BMI) taken over a span of 28 years, from 1971 to 1998, in the Framingham Heart Study. Variance-components linkage analysis was performed on 330 families, using 401 polymorphic markers. The number of ...

Genomewide Linkage Analysis of Body Mass Index across 28 ...

Genome-Wide Linkage Analysis of Large Multiple ...

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7/14/2017 · In contrast to sib-pair analysis of 428 nuclear families in our previous study 40, genome-wide linkage analysis was carried ... The principle of the Genehunter linkage analysis is to examine any ...

Genome-Wide Linkage Analysis of Large Multiple ...

Linkage analysis of alcohol dependence using MOD scores ...

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12/30/2005 · In particular, we performed parametric single-marker linkage analysis using MLINK of the LINKAGE package (for the microsatellite data), as well as multipoint MOD-score analysis with GENEHUNTER-MODSCORE (for the microsatellite and SNP data). By use of two liability classes, different penetrances were assigned to males and females.

Linkage analysis of alcohol dependence using MOD scores ...

Linkage analysis of the simulated data – evaluations and ...

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12/31/2003 · The goal of this study is to evaluate, compare, and contrast several standard and new linkage analysis methods. First, we compare a recently proposed confidence set approach with MAPMAKER/SIBS. Then, we evaluate a new Bayesian approach that accounts for heterogeneity. Finally, the newly developed software SIMPLE is compared with GENEHUNTER. We apply these methods to …

Linkage analysis of the simulated data – evaluations and ...

Genetic linkage studies - The Lancet

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9/17/2005 · Linkage analysis is used to map genetic loci by use of observations of related individuals. We provide an introduction to methods commonly used to map loci that predispose to disease. Linkage analysis methods can be applied to both major gene disorders (parametric linkage) and complex diseases (model-free or non-parametric linkage). Evidence for linkage is most commonly expressed …

Genetic linkage studies - The Lancet

GENEHUNTER: Application to analysis of bipolar pedigrees ...

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TY - JOUR. T1 - GENEHUNTER. T2 - Genetic Epidemiology. AU - Li, Hongzhe. AU - Schaid, Daniel J. PY - 1997. Y1 - 1997. N2 - A newly developed nonparametric multipoint linkage analysis (NPL) by Kruglyak et al. [1996] was applied to the data set from the Johns Hopkins Bipolar Study available through the GAW10 workshop.

GENEHUNTER: Application to analysis of bipolar pedigrees ...

Genetic linkage analysis in the age of whole-genome ...

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3/31/2015 · For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by …

Genetic linkage analysis in the age of whole-genome ...

Genomewide Linkage Analysis of Weight Change in the ...

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Genomewide Linkage Analysis of Weight Change in the ...

Genomewide Linkage Analysis of Weight Change in the ...

Linkage analysis of the simulated data – evaluations and ...

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The goal of this study is to evaluate, compare, and contrast several standard and new linkage analysis methods. First, we compare a recently proposed confidence set approach with MAPMAKER/SIBS. Then, we evaluate a new Bayesian approach that accounts

Linkage analysis of the simulated data – evaluations and ...

Linkage and association with pulmonary function measures ...

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11/1/2003 · For this study, additional markers were genotyped in the region to refine the location of linkage and test for association. Variance component linkage analysis was performed using GENEHUNTER, and family-based association tests were performed using FBAT.

Linkage and association with pulmonary function measures ...

73 questions in Linkage Analysis | Science topic

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Mind you, linkage disequilibrium is only a problem for multipoint linkage analysis, and when founders are missing. A few answers above mention 'highly informative SNPs'. 'Informative' in linkage ...

73 questions in Linkage Analysis | Science topic

Linkage analysis of ordinal traits for pedigree data - PNAS

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Linkage analysis of ordinal traits for pedigree data Rui Feng†, James F. Leckman‡, and Heping Zhang†‡§ †Department of Epidemiology and Public Health and ‡Yale Child Study Center, Yale University of School of Medicine, New Haven, CT 06250-8034 Edited by David O. Siegmund, Stanford University, Stanford, CA, and approved September 29, 2004 (received for review June 29, 2004)

Linkage analysis of ordinal traits for pedigree data - PNAS

Genome-Wide Linkage to Chromosome 6 for Waist ...

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5/1/2004 · While several loci for BMI have been identified, it is not known whether genes underlie the process of regional fat deposition. We sought to test whether waist circumference, a measure of central adiposity, contains a genetic component. Variance components linkage analysis was performed on 330 families from the Framingham Heart Study original and offspring cohorts, using a 10-cM genome-wide ...

Genome-Wide Linkage to Chromosome 6 for Waist ...

Genome-wide linkage analysis to age at natural menopause ...

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The first genome-wide linkage study of variation in age at natural menopause identified a significant locus on the X chromosome and a suggestive locus on chromosome 9 (7 x 7 van Asselt, K.M., Kok, H.S., Putter, H., Wijmenga, C., Peeters, P.H., van der Schouw, Y.T. et al. Linkage analysis of extremely discordant and concordant sibling pairs ...

Genome-wide linkage analysis to age at natural menopause ...

Comparison of GENEHUNTER and MFLINK for analysis of COGA ...

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We compared the NPL ALL statistic from GENEHUNTER with two-point and three-point MALODs and MFLODs from MFLINK for all autosomal markers in the Collaborative Study on the Genetics of Alcoholism (COGA) data set. In general MFLINK produced more significant results than GENEHUNTER and implicated two regions containing candidate genes (ADH3 and DRD2).

Comparison of GENEHUNTER and MFLINK for analysis of COGA ...
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