Coin study oncology

Addition of cetuximab to oxaliplatin-based first-line ...

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This trial has not confirmed a benefit of addition of cetuximab to oxaliplatin-based chemotherapy in first-line treatment of patients with advanced colorectal cancer. Cetuximab increases response rate, with no evidence of benefit in progression-free or overall survival in KRAS wild-type patients or even in patients selected by additional mutational analysis of their tumours.

Addition of cetuximab to oxaliplatin-based first-line ...

Intermittent chemotherapy plus either intermittent or ...

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COIN-B was designed as an exploratory, hypothesis-generating study to complement COIN. At randomisation, only infusional fluorouracil in combination with oxaliplatin and cetuximab was allowed, which removed the confounding effect and possible negative interaction reported in COIN and other studies when capecitabine was the partner fluoropyrimidine.

Intermittent chemotherapy plus either intermittent or ...

Initial COIN study results presented at European Oncology ...

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The COIN study was designed to evaluate whether the addition of Erbitux® ... Oncology, Merck Serono, a division of Merck KGaA, Darmstadt, Germany. “Further analysis of the dose intensity and 2nd-line treatment, and other factors, such as the advanced disease of patients in the study, are ongoing to determine why the COIN results are not ...

Initial COIN study results presented at European Oncology ...

Extended RAS mutations and anti-EGFR monoclonal antibody ...

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5/20/2009 · Christophe Le Tourneau, J. Jack Lee, and Lillian L. Siu Phase I clinical trials are an essential step in the development of anticancer drugs. The main goal of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding ...

Extended RAS mutations and anti-EGFR monoclonal antibody ...

Dose Escalation Methods in Phase I Cancer Clinical Trials

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the Netherlands. 2Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Depart- ... patients in the CAIRO2 study, 1,461 patients in the COIN study, and 764 patients in the FOCUS study. The prevalence of MMR status and BRAFMT status and their correlation are presented in Tables 1 and 2 ...

Dose Escalation Methods in Phase I Cancer Clinical Trials

Mismatch Repair Status and BRAF Mutation Status in ...

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Derived neutrophil to lymphocyte ratio as a prognostic factor in patients with advanced colorectal cancer according to RAS and BRAF status: a post-hoc analysis of the MRC COIN study. Wood G(1), Grenader T, Nash S, Adams R, Kaplan R, Fisher D, Maughan T, Bridgewater J.

Mismatch Repair Status and BRAF Mutation Status in ...

Derived neutrophil to lymphocyte ratio as a prognostic ...

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Grief and acceptance as opposite sides of the same coin: setting a research agenda to study peaceful acceptance of loss - Volume 193 Issue 6 - Holly G. Prigerson, Paul K. Maciejewski

Derived neutrophil to lymphocyte ratio as a prognostic ...

Grief and acceptance as opposite sides of the same coin ...

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2/18/2016 · The trial design and eligibility criteria have been reported previously (Adams et al., 2011).The primary objective of the phase 3 MRC COIN study was to assess the effect of pre-planned treatment ...

Grief and acceptance as opposite sides of the same coin ...

Derived neutrophil lymphocyte ratio is predictive of ...

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See more of The Christie School of Oncology on Facebook. Log In. Forgot account? or. Create New Account. Not Now. The Christie School of Oncology. February 12, 2018 · Are you wondering what our Peritoneal Metastatic Colorectal Cancer Study Day is all about? Here's Mr Omer Aziz, Consultant Colorectal & Laparoscopic Surgeon at The Christie, to ...

Derived neutrophil lymphocyte ratio is predictive of ...

The Christie School of Oncology - Peritoneal Metastatic ...

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If you choose to be in this study, you will: - Be randomized (put into one of two groups by chance like a flip of a coin) to either: --- Group 1: lenvatinib capsules and pembrolizumab infusion (study drugs) --- Group 2: Get either doxorubicin or paclitaxel infusions - Get study drugs every 3 weeks for 3 cycles - Have follow-up visits every 8 ...

The Christie School of Oncology - Peritoneal Metastatic ...

Gynecologic Cancer Clinical Trials | Duke Cancer Institute

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Using a retrospective biomarker analysis of two clinical trials -- the Short Course in Oncology Therapy (SCOT) and COIN/COIN-B trials -- the authors of this study find an association of loss of function single nucleotide polymorphisms with oxaliplatin benefit in colorectal cancer.

Gynecologic Cancer Clinical Trials | Duke Cancer Institute

JNCI: Journal of the National Cancer Institute - Home ...

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In computer science and information science, an ontology encompasses a representation, formal naming, and definition of the categories, properties, and relations between the concepts, data, and entities that substantiate one, many, or all domains.. Every field creates ontologies to limit complexity and organize information into data and knowledge.As new ontologies are made, their use hopefully ...

JNCI: Journal of the National Cancer Institute - Home ...

Ontology (information science) - Wikipedia

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Derived neutrophil to lymphocyte ratio as a prognostic factor in patients with advanced colorectal cancer according to RAS and BRAF status: a post-hoc analysis of the MRC COIN study

Ontology (information science) - Wikipedia

Stephen Nash's research works | Cancer Research UK, London ...

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The Editor Current Oncology April 18, 2013 Market Velker et al.1 recently reported an unusual case of adenocarcinoma arising from the minor salivary gland located on the dorsum of the posterior ...

Stephen Nash's research works | Cancer Research UK, London ...

Current Oncology | RG Journal Impact Rankings 2017 and 2018

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Choose from 500 different sets of disease states oncology flashcards on Quizlet. ... Browse 500 sets of disease states oncology flashcards. Study sets. Diagrams. Classes. Users Options. 13 terms. emily_kahlig5. pulmonary oncology and disease states. coin lesion- solitary pulmonary nodule. most common type of lung cancer.

Current Oncology | RG Journal Impact Rankings 2017 and 2018

disease states oncology Flashcards and Study Sets | Quizlet

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disease states oncology Flashcards and Study Sets | Quizlet

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5/28/2014 · Learn how to pass the OCN exam and be prepared for your test day. Find out about OCN exam study resources and practice that is available online. OCN Study G...

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How to pass the OCN Exam! - YouTube

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Adams, R.A., Meade, A.M., Seymour, M.T. and 17 others, on behalf of the MRC COIN Trial Investigators (2011) Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial, The Lancet Oncology, published online ahead ...

How to pass the OCN Exam! - YouTube

Intermittent versus continuous chemotherapy in advanced ...

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10/1/2011 · Phase I Pharmacokinetic and Pharmacodynamic Dose-Escalation Study of RG7160 (GA201), the First Glycoengineered Monoclonal Antibody Against the Epidermal Growth Factor Receptor, in Patients With Advanced Solid Tumors ... American Society of Clinical Oncology Policy Statement: Opportunities in the Patient Protection and Affordable Care Act to ...

Intermittent versus continuous chemotherapy in advanced ...

Journal of Clinical Oncology: Vol 29, No 28 - ascopubs.org

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The role of cetuximab in converting initially unresectable colorectal cancer liver metastases for resection ... the European Society for Medical Oncology ... phase 3 COIN study did not report an increase in potentially curative liver resections—despite an increase in ORR—with the addition of cetuximab to oxaliplatin-based chemotherapy in ...

Journal of Clinical Oncology: Vol 29, No 28 - ascopubs.org

The role of cetuximab in converting initially unresectable ...

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The role of cetuximab in converting initially unresectable ...
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